| 1930 | The College was authorized to confer the degree Bachelor of Science in Education. |
| The school received permission to offer a three-year course in Commerce. | |
| The De La Salle Alumni Association was organized. | |
| Br. Dorothy Joseph FSC was named DLSC President. He would serve the post until 1933. | |
| 1932 | De La Salle College was awarded the official diploma of Catholic Action by Archbishop Michael O’ Doherty in recognition of the school’s activities to enhance Catholicity among its students. |
| 1933 | On behalf of other private schools, De La Salle College, University of Santo Tomas, and Ateneo de Manila drafted a memorandum on the right of private schools to government recognition, at which time the Bureau of Education wanted to take over their supervision. |
| Br. Marchian James FSC was named DLSC President. He would serve the post until 1936. | |
| 1934 | The College Band made its first public appearance at the opening of the Basketball Tournament. |
| La Sallite, a literary/news bi-weekly was launched in September. | |
| 1935 | De La Salle won the NCAA Track and Field championship. |
| 1936 | The College of Education was established. |
| The Reserve Officers’ Training Corps (ROTC) program was established. | |
| Br. Flannan Paul FSC was named DLSC President. | |
| 1937 | Br. Egbert Xavier FSC was named DLSC President, a post he would serve until 1945. |
| 1939 | The Most Blessed Sacrament Chapel was built. |