| 1960 | In October, the maiden issue of the LaSallian was released as the official student publication of De La Salle College. |
The Office of the Guidance Department was inaugurated. |
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The Graduate School of Business was established. |
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| 1961 | The De La Salle College logo was changed. |
| Br. Crescentius Richard FSC was named La Salle President. He would serve the post until 1966. | |
| 1962 | Br. Nicet Joseph FSC, the first Superior General to visit the Philippines, was awarded the Pro Ecclesia et Pontifice Medal, and a Ph.D. in Education, honoris causa, by De La Salle College. |
| The “Alumnews”, the official newsletter for the alumni, was released. | |
| 1963 | The Graduate School of Education, Arts and Science was established as a response to the need of upgrading secondary education in the country. |
| 1964 | The Graduate School of Education, Arts and Sciences availed the services of the Mathematics department for the mathematics course offerings of the Master of Arts in Education program. |
| 1965 | The Management Development Program, a non-degree program for seminars and management training, was established. |
| 1966 | Br. Hyacinth Gabriel FSC was named DLSC President. He would serve the post until 1978. |
| 1967 | The appointment of Rev. Br. Javier Quintos FSC, as De La Salle Grade School principal by De La Salle College President Rev. Brother Hyacinth Gabriel Connon FSC marked the first assignment of the important post to a Filipino Brother. Br. Javier was the youngest principal in the history of the De La Salle Grade School Department. |
| 1968 | The High School Department was dissolved. |
| De La Salle University, Ateneo de Manila University and University of the Philippines formed the MBA Consortium. | |
| 1969 | The four-storey St. Benilde Hall was built. It is now named St. Miguel Hall. |
| De La Salle University, Ateneo de Manila University and University of the Philippines created the Asian Institute of Management (AIM). | |
| Elections for the Student Council officers were held for the first time. |