| 1980 | The William J. Shaw Auditorium (Little Theatre) was dedicated and blessed. |
| 1981 | The academic council approved the first Ph.D. program. |
| The University shifted its academic calendar from the traditional semester schedule to a year-round trimester calendar. | |
The Center for Planning, Information, and Computer Science (now known as the College of Computer Studies) was established, offering a Bachelor of Science degree in Computer Science. |
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| The new Engineering building (Velasco Hall) was completed. | |
| The Integrated Research Center was organized into two units: The University Research Office (URO) and the External Research Office (ERO). | |
| 1982 | The College of Science was formed when the departments of Biology, Chemistry, Mathematics and Physics separated from the College of Arts and Sciences. |
| The Medrano Study Hall located on the second floor of the St. La Salle Hall was inaugurated. | |
| A three-storey integrated warehouse and maintenance building was built. | |
| 1983 | The De La Salle Green Archers captured the 1983 National Open Seniors Championship in NCAA. |
| The De La Salle University Press was set up as part of the University’s Research Center. | |
| De La Salle University celebrated a Mission Statement Week for the first time, affirming the philosophical framework for the existence of the institution and its programs. | |
| The statue of St. John Baptist de La Salle at the Marian Quadrangle was blessed on June 16. | |
| 1984 | The Center for Planning, Information, and Computer Science was formally declared as the College of Computer Studies. |
| The last remaining 120 seventh graders graduated on March 24, with Josefina H. Alburo as the last grade school principal. | |
| Ang Pahayagang Plaridel was first released as the official student publication of the university in Filipino. | |
| 1985 | The University Library building was inaugurated. |
| DLSU-PUSO (Parents of University Student Organizations) was established. | |
| Dr. Emerita Quito of the Philosophy Department won the first Metrobank Search for Outstanding Teachers. The Metrobank Award has since grown to become a highly anticipated national search for teaching excellence and service. | |
| 1986 | De La Salle University joined the University Athletic Association of the Philippines (UAAP). |
| The Philippine Uplands Resource Center (PURC) was set up by a consortium of institutions that included the DLSU Research Center, the Institute of Philippine Culture of the Ateneo de Manila University, the College of Forestry and Institute of Environmental Science and Management of the University of the Philippines, and the Forest Management Bureau of the Department of Environment and Natural Resources. | |
| 1987 | The De La Salle University System was established under the term of Br. Andrew Gonzalez FSC. Members included De La Salle University, De La Salle University-Dasmarinas, De La Salle Santiago Zobel, De La Salle-College of Saint Benilde, and De La Salle-Health Sciences Campus. |
| The Information Technology Center developed a computerized registration system for the Graduate School of Business and Economics. | |
The De La Salle University Chorale was established. |
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| De La Salle University Press became autonomous from the University’s Research Center. | |
| 1988 | The University Archives was established. |
| 1989 | St. Benilde Hall was renamed St. Miguel Hall. |
| De La Salle University Library became one of the founding members of the Department of Science and Technology-Engineering and Science Education Project (DOST-ESEP) Library Consortium. |