|2000||In August, Microsoft honored the College of Computer Studies as its sole Philippine Academic Partner.|
The University’s physical facilities projects included the demolition of the Br. Lucian Athanasius Gymnasium, the renovation of the Most Blessed Sacrament Chapel, and the re-construction of theBr. John Hall.
|The Commission on Higher Education (CHED) granted De La Salle University “autonomy and deregulated status” effective second term of Academic Year 2000-2001.|
|The American Corner, formerly known as the American Studies Resource Center, was established when the University Library received in May a donation of the library collection of the former Thomas Jefferson Information Center from the Embassy of the United States in Manila.|
The La Salle Institute of Governance was established.
DLSU-Professional Schools Inc. (PSI) inaugurated a satellite campus at RCBC Plaza in Makati City.
|The DLSU Wireless Information Services (DLSU WISe) was launched. The system allows community members to receive announcements, such as final exam schedules, UAAP standings, or class suspensions via text messaging.|
|2002||The National Service Training Program (NSTP) was implemented. In line with Republic Act (RA) No. 9163, the program provides Lasallian freshmen the option to take either the Reserve Officers' Training Corps (ROTC) or Civic Welfare Training Service (CWTS).|
De La Salle University was granted Level IV status by the Philippine Accrediting Association of Schools, Colleges and Universities (PAASCU).
|The Don Enrique T. Yuchengo Hall was completed.|
The ASEAN University Network Inter-Library Online (AUNILO) was established. The University hosted the first conference of AUNILO.
|A smart e-classroom, later named as the Phinma Electronic Classroom, was launched.|
|The DLSU Art Gallery was relocated on the second floor of the Yuchengco Hall.|
|With the success of the Micro-Hydro Plant (MPH) project in Malibcong, Abra, De La Salle University established the Center for Micro-Hydro Technology for Rural Electrification Project to promote MHP technology to other communities around the country.|
|2003||Dr. Carmelita Quebengco was appointed as the Interim University President.|
|De La Salle University set up the Biomedical Engineering program.|
|2004||The Enrique M. Razon Sports Complex was inaugurated.|
|Br. Armin Luistro FSC was named University President. He would serve the post for the next six years.|
|The Transformative Learning Framework was introduced.|
|The College of Computer Studies was reintegrated into the DLSU System.|
|The Museum at De La Salle University was inaugurated.|
DLSU-Manila conferred on Br. Andrew Gonzalez FSC the title
|A WIFI facility was enabled within the University.|
|The College of Computer Studies (CCS) garnered Level III accreditation for its BS Computer Science program. Likewise, the CCS Computer Technology Department became the first Cisco Academic Training Center in the Philippines.|
All of the University’s Science and Mathematics programs were granted the recognition of Center of Excellence in the Philippines by the Commission on Higher Education.
|In July, the Ramon del Rosario Sr. Graduate School of Business became autonomous.|
|De La Salle Philippines was established to include all La Salle schools in the country.|
|DLSU became the first University in the country to be designated as Microsoft Innovation Center. A Microsoft Research Laboratory to pursue research and development, especially in the area of mobile phone applications, was also established.|
|DLSU introduced the Hybrid Program, a comprehensive online learning program that combines online sessions and classroom teaching.|
|2007||Brother Andrew Gonzalez Hall, a 20-storey tall building was inaugurated on March 1 in celebration of the 67th birthday of the late Br. Andrew Gonzalez FSC.|
The College of Computer Studies was recognized as a Center of Excellence for Information Technology by the Commission on Higher Education (CHED).
|CHED also granted the University a five-year autonomous status.|
The St. La Salle Preschool building located on Fidel Reyes St., Manila was constructed.
Students and faculty of the College of Engineering designed, built, and raced SINAG, the first solar powered car in the Philippines to compete in the World Solar Car Challenge in Adelaide, Australia.
|2008||The Ramon del Rosario, Sr. Graduate School of Business was reintegrated into DLSU’s College of Business and Economics.|
|The College of Education was awarded the distinction of Center of Excellence in Teacher Education by the Commission on Higher Education (CHED).|
|The ASEAN University Network (AUN) visited DLSU for the second AUN-Quality Assurance Actual Assessment of the Chemical Engineering and Economics programs.|
|A linkage with the Apalit Vocational/Technical High School, renamed as the Br. Andrew Gonzalez Vocational/Technical High School in honor of the late DLSU President and visionary leader, was established.|
|The Asia-Pacific Education Researcher of the College of Education became the first Filipino journal from a private university to be included in Thomson Scientific.|
|2009||The DLSU Graduate Student Council was established.|
Shalom Center, a wellness facility for exclusive use of the university’s faculty and other employees, was opened.
|The Compliance Office was established to ensure the community’s adherence to internal and external laws and to promote standardization of work practices.|
|The Technology-Enabled Learning Environment (TELE) Project was approved by the President’s Council. The project intends to convert every classroom into a standard TELE classroom equipped with Internet access, LCD projectors, and thin- client computers with high-end speakers.|
President and Chancellor Br. Armin Luistro FSC was elected to head the International Association of Lasallian Universities (IALU).
|The Center for Empathic Human-Computer Interactions (CEHCI) of the College of Computer Studies had a demonstration of the Philippine’s first physical empathic computing space.|
|2010||SIKAT, the second solar powered car produced by the College of Engineering faculty and students, made a historic 50-day tour across the country.|
|The College of Law opened in the first trimester of Academic Year 2010-2011.|
|The College of Business and Economics was restructured into two entities, namely the College of Business and the School of Economics.|
|Br. Armin Luistro FSC was appointed as Education Secretary.|
|Br. Narciso Erguiza, Jr. FSC was named the 21st President of DLSU.|
|Br. Ricardo Laguda FSC was appointed as the third Chancellor of DLSU.|